Greenville Hospital System University Medical Center (GHS), one of the state's most comprehensive not-for-profit healthcare networks, offers what other area hospitals cannot – the latest medicine, surgery, research and education. Its continuum of care provides seamless, leading-edge support from prevention and diagnosis through treatment and recovery. With five campuses and multiple primary and specialty practices, GHS offers health care that is both advanced and accessible.

The new Greer Medical Campus is available to residents of the Greer, Taylors, Eastside and surrounding communities. The new campus, located on S. Buncombe Road in Greer, features the new, state-of-the-art Greer Memorial Hospital, Greer Medical Office Buildings and The Cottages at Brushy Creek, as well as other free-standing physician practices.

The Patewood Medical Campus located on the Eastside features Patewood Memorial Hospital and Patewood Medical Office Buildings. Patewood Memorial Hospital is an elective, short-stay hospital that encompasses a philosophy of patient-centered care. Patewood Medical Office Buildings feature a variety of outpatient services including the Vascular Institute for Health, the Musculoskeletal Institute for Health and Wellness, and specialized Children's Outpatient Services.

The Simpsonville Medical Campus is conveniently located off of S. Main Street in Simpsonville and serves residents of Simpsonville, Mauldin and Fountain Inn. The campus hosts Hillcrest Memorial Hospital and Hillcrest Medical Office Buildings. Hillcrest Memorial Hospital has been designated a Center of Excellence by the American Society of Bariatric and Metabolic Surgery.

Greenville Memorial Hospital (GMH) is the flagship facility for the Greenville Hospital System. It is a community hospital for the surrounding communities and a regional referral center for specialized services such as heart, cancer, rehabilitation, women's and children's health care. With 750 beds, GMH is one of South Carolina's largest acute care hospitals and offers the state's largest cardiac and women's services. Other specialty programs include Marshall I Pickens Hospital – Behavioral, sleep center, HeartLife cardiac rehabilitation and outpatient surgery, as well as a medical office building with primary and specialty care physician practices. The campus also includes a Life Center for health and fitness.

The North Greenville Medical Campus North Greenville Long Term Acute Care Hospital (LTAC) and outpatient services. LTAC is an inpatient hospital for adult patients with complex medical conditions requiring a stay longer than 18 days. Not a nursing home, this facility specializes in complicated cases that require both an interdisciplinary approach and mindset determined to get the patient on to the next step on the continuum of care and back to a quality life. North Greenville also offers 24-hour emergency care that employee the same physicians that rotate through all Greenville Hospital System emergency departments, outpatient laboratory, x-ray and CT as well as physician services for pediatrics and orthopaedics.