Below are the final scores from week 5 high school football games:
- Hillcrest 17 - Greenwood 56
- Christ Church 48 - Calhoun Falls 0
- Emerald 72 - West Oak 7
- Wren 28 - Seneca 27
- Whitmire 0 - Dixie 47
- Wade Hampton 37 - Mauldin 64
- Liberty 29 - Landrum 33
- Ninety Six 21 - Woodruff 41
- Union 35 - Newberry 28
- Southside Christian 14 - Ware Shoals 46
- JL Mann 21 - TL Hanna 55
- Westside 14 - Woodmont 13
- Pendleton 17 - Blacksburg 14
- Boiling Springs 7 - Byrnes 35
- Dorman 0 - Gaffney 14
- Greenville 10 - Southside 6
- Crescent 48 - Powdersville 12
- Eastside 6 - Pickens 12
- Carolina 6 - Chesnee 38
- Travelers Rest 17 - Greer 56
- Abbeville 24 - Clinton 22
- Laurens 27 - Easley 16
- Spartanburg 54 - Riverside 3
- Berea 7 - Blue Ridge 52
- St. Joseph's 14 - McCormick 32
- Daniel 35 - Palmetto 0
- BHP 58 - Walhalla 0
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