Information contained on this page is provided by an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith. If you have any questions or comments about this page please contact email@example.com.
SOURCE The Austrian Centre of Industrial Biotechnology (ACIB)
Today most medicines are produced biotechnologically. A new cleaning method developed at ACIB combines five purification steps and leads to an extremely facilitated, more economical and ecological manufacturing process.
GRAZ, Austria, June 12, 2014 /PRNewswire/ -- Seven of the ten best-selling drugs in 2012 were biopharmaceuticals; biotechnology in pharmaceutical production is still growing. A severe problem is the cleaning of products; up to 80% of the total production costs are spent for protein purification. The Austrian Centre of Industrial Biotechnology (ACIB) has developed a method based on microparticles, which reduces five purification steps to only one; a revolution in the cleaning process of biopharmaceuticals.
"Our micro-particle system comprises a new cleaning method especially for proteins for medical application, which are produced by microorganisms. Using our microparticles, the manufacturing process of biopharmaceuticals becomes qualitatively better and faster," explains Prof. Bernd Nidetzky, CSO of ACIB. The new process was developed within a cooperation of ACIB and Boehringer Ingelheim RCV.
"Five in one"
"The economic relevance of this new purification method lies in its simplicity and speed. We aggregated five process steps into a single one," says Georg Klima, head of Process Development Biopharma at Boehringer Ingelheim in Vienna, "in addition, we expect an even better quality because the microparticles directly absorb the product out of the cells with high specifity." A key issue was the transfer of technology from research into corporate laboratories, which was completed within a few weeks.
Details about the microparticle technology
Currently, chromatography is used for standardized protein purification. Industry fights with slow binding rates, clogged or damaged material, product losses and other obstacles.
The new ACIB system works differently: Scientists prepare charged microparticles based on the ion exchange principle with a size of one to two microns. The entire binding operation is completed within 30 seconds. Additionally, a continuous process based on the micro particle technology has been established to further accelerate the biopharmaceutical purification.
ACIB is an international research center and a partnership of 80+ universities and industry partners. At acib, 190+ scientists work in more than 40 research projects searching for new, more economic and ecological technologies.
Mobius Learning specializes in creating custom learning solutions that are focused on improving human performance. Whether those solutions are designed for Fortune 500 employees or struggling middle school students, Mobius Learning accelerates human growth and effectiveness using the most advanced technology and instructional design methodologies. The goal is to produce a highly interactive experience that not only facilitates knowledge transfer, but also changes the behavior of the user and ultimately improves ROI. Mobius Learning also offers custom LMS and blended learning solutions, as well as iOS and Android app development.
This press release was issued through 24-7PressRelease.com. For further information, visit http://www.24-7pressrelease.com.
©2012 PR Newswire. All Rights Reserved.