Eastbound lanes on SC Highway 80 will close Friday evening and remain closed until Monday, according to the SCDOT.
Officials said the eastbound lanes, heading toward Lyman, will close at SC 290 at 6 p.m. while crews make repairs to the approach at the SC Highway 290 overpass.
A 14-mile detour route has been marked. The detour route is along SC 101, I-85 and US 29.
Westbound lanes of SC 80, toward Greer, is not affected by the closure.
The eastbound lanes are expected to reopen Monday morning.
MORE TRAFFIC NEWS: City of Greenville announces maintenance, event road closures
Copyright 2017 FOX Carolina (Meredith Corporation). All rights reserved.
See photos of FOX Carolina reporters, anchors, and staffers from their school days.
Upstate students head back to the classroom for the 2017-18 school year.
The Greenwood County Sheriff's Office released photos from a crash that led to the apprehension of an escaped inmate.
Niche.com released a ranking of the hardest colleges to get into in South Carolina for 2017.