Coroner Greg Shore said he was called to a crash on High Shoals Road at Abbeville Highway around 6:45 a.m.
Troopers said the victim was driving a 2004 Kia four-door that ran off the road and flipped. The driver became entrapped in the vehicle and died at the scene.
The coroner identified the victim as 63 year-old William Michael Fowler of Anderson. Shore said that Fowler died from a head injury and was not wearing a seat belt.
According to the coroner, icy road conditions were a contributing factor to the collision. This crash was one of at least 20 in Anderson County and 60 in the Upstate that troopers responded to Tuesday morning.
Click here to see the current list of crashes in the area from the SCHP.