Spartanburg Emergency Management said a Great Dane puppy and a cat are missing after a crash involving an overturned tractor trailer and a Jeep Cherokee that shut down I-26 East near mile marker 15 in Spartanburg County for several hours early Thursday morning.

Four people were also taken to the hospital after the crash: three from the Cherokee and the driver of the tractor trailer.

Below is what the agency posted on Facebook about the incident:I-26 eastbound at Hwy 176 is now back open. Eastbound tractor trailer went into median, then back onto roadway where it overturned across both eastbound lanes. 3 ladies from Ohio in a Jeep Cherokee also traveling eastbound, unable to see the trailer across both lanes due to dark/rainy conditions, struck the overturned trailer. All 3 were extricated and transported to the hospital, along with driver of the semi truck, all with non life threatening injuries. A 6 month old white Great Dane puppy and a cat (unk description) ran from the Jeep after the crash and have not yet been found. Truly a miracle everyone survived this serious accident! Great work by N Sptbg FD, Sptbg EMS, Sptbg Co Sheriff’s Office, SCHP, SC Transport Police, SCDOT and Revelation Towing on a cold rainy night!The crash happened shortly after 1 a.m. and injuries were reported, according to the SC Highway Patrol website.

Troopers advised drivers to avoid the area while crews were working to clear the wreckage and offered this detour route: Take I-26 east to exit 15 then travel US-176 east towards Spartanburg, then take I-85 south back to I-26 east at exit 70.By 6:15 a.m. the truck had been moved from the roadway and the interstate reopened to drivers.

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